(Photo Mechanic 4.6.3 running under XP SP2)
When "Subsample Chroma" is selected, what is the most likely effect you'd see in terms of degradation of the image?
I've been trying "Save as" tests with and without this setting selected. In the output files, I can't detect any differences except for possibly a very, very slight increase in apparent sharpness in the files saved with "Subsample Chroma" selected. (I'm not using the Sharpen option, so I'm wondering if this difference might be caused by some very slight increase in contrast. Admittedly, it does take an almost-neurotic degree of pixel-peeping to see the difference.)
Images saved for web display at reduced sizes do sometimes need a bit of additional sharpening -- but not as much as they get in PM at the moment. In my experience so far, the 'sharpen' feature produces visible sharpening artifacts.
The 'save as' feature is excellent -- exactly what I've been looking for in a save-for-web routine. I hope that some day the amount of sharpening could be a user option.