I believe the official EXIF standard allows only an unsigned short integer for ISO rating, that would indeed be 2 bytes with 65535 maximum value. At least that comes to my mind from remembering reading the specs (just lightly browsing them though).
Also, it's worth noting that all current high-ISO cameras only have "official" ISO up to 25600. All values after that are denoted as ISO Expansion, be it Low, High 1, High 2, etc. I guess the actual High-x is stored in the makernotes, and if the new Canon has a new format or changed makernote field for the "High" ISO expansion, it would of course be currently not viewable in current versions of PM/Exiftool.