I have emailed DXO and sent them a file. Here is their reply:
When the original file information we need is changed, or even shifted by a single byte, the process to extract the information Optics Pro needs from the image file can fail. We use precise file information provided to us by the camera manufacturers. Therefore, when the information in the file no longer follows their specifications, that can cause issues. And yes, our developers have investigated this issue in the past.
If other programs want to absolutely insure that no changes are made to image files that they use, one suggestion would be that they follow the Adobe model. Adobe allows their customers to write any changes made to an image file to a sidecar file. Therefore, the original file is left in the exact same state as it came from the camera. Adobe does this with their .xmp files, and it allows our customers to successfully use files that have been used in programs such as Adobe Bridge.
As I noted, thank you for writing back and for your input, and I appreciate your taking time to write to us.
If you have any other questions regarding the use of Optics Pro, please feel free to contact us.
regards,
Jeff
DxO Support Team
DxO Labs