Weird, I always use LZW compression on my TIFFs and I have never had any problems with them. Be they saved from NX2 or Photoshop…
I do, however, use only PM to edit the meta data.
Curious, I just tested altering IPTC/XMP data of a (tiff) file within Capture NX2 to see what happens when you do so. What I found was that if I altered (e.g., added a keyword) the meta data, NX2 stripped-out the label and rating fields from the meta data. The ratings would still show as they are still present in another form somewhere in the meta data, the colour class strangely enough would not show any more, though NX2 previously understood it perfectly fine. This clearly is a bug in NX2.
So once again I am happy to never edit IPTC/XMP meta data within NX2 as it is clearly buggy…
Hope this sheds some light at your problem too.