I'm using a Wacom Intuos 4 medium size, bought several years ago, model PTK-640. There might be various items I've set in the Wacom tablet properties, but nothing radical.
There is a mouse scroll wheel issue, where scrolling the mouse wheel causes the mouse pointer to jump to another part of the screen if I have the tablet working across my two displays. I spent a lot of time with Wacom trying to get this resolved, but no luck. It used to work fine, but then just started happening (I think about a year ago). I suspect something in a Windows 10 update. If the tablet is assigned to only one display, the scrolling isn't an issue. Just in case that's the issue, I just tried the PM6+ catalog again with the tablet assigned to only one display, but no luck with that either.
Otherwise nothing special or any.
The only other input-related item that I can think of is that due to an accident, I couldn't use my left hand for a couple of months, so I turned Windows "Sticky Keys" on. Weirdly, now my computer starts with "Sticky Keys" turned on, even though it looks like it's configured not to. However, by the time I'm trying to use the Catalog feature, I've already turned sticky keys off manually.
One thing I just noticed: when the Catalog window goes unresponsive, I can still click the X upper right on the main Photo Mechanic window, and both windows shut down. FWIW, the main PM window closes first, then the catalog window. (So I didn't have to be using Task Manager all this time...)